Peptide
Coriolis Pharma specializes in formulation development and drug product development for peptides. We offer a range of stability-indicating and phase-appropriate analytical methods tailored to peptide characterization.
Each peptide presents unique challenges, requiring specific solutions for issues like solubility and the impact of counterions. Our experts leverage extensive experience in peptide stability studies and forced degradation studies to ensure robust and stable formulations. We also address high peptide concentration challenges, minimizing issues like gelation, fibrillation and chemical degradation.
Peptide Services
Coriolis Pharma’s deep expertise in formulation science and experience with a variety of peptide-based therapeutic drug products equip us to support the entire product lifecycle.
Specialized Peptide Services and Capabilities
Coriolis science-driven solutions are based on our deep understanding of the specific challenges of developing a peptide drug product. Our expert scientists will devise dedicated study designs tailored to the needs of your product and development phase.
Solubility Optimization and pH Adjustments
The aqueous solubility of a peptide depends on the solution pH, requiring a stable formulation in an optimal pH range to maximize solubility and minimize chemical degradation. Coriolis excels in peptide formulation development by selecting suitable stabilizing excipients. We use a wide range of analytical techniques to perform stability and forced degradation studies, identifying critical degradation pathways and choosing the best formulation approach.
High-Concentration Peptide Formulation Development
High-concentration formulations, essential for applications like subcutaneous and intravitreal injections, offer an alternative to intravenous use. We develop both liquid and lyophilized high-concentration formulations. Our scientists are skilled in addressing challenges of aggregation, viscosity, syringeability and manufacturability.
Low-Concentration Peptide Formulations
Highly potent peptides, like hormones, need low-concentration formulations, posing challenges like surface adsorption and requiring high-sensitivity analysis. Our scientists excel in developing low-dose formulations, both liquid and lyophilized. We provide specialized analytical techniques and sensitive characterization methods tailored to your peptide therapeutic.
Peptide Resources
Publications
March 1, 2019
Publications
February 25, 2019
Publications
January 1, 2019
Comprehensive Biotherapeutic Expertise
Our deep-rooted academic background, drug development and commercialization expertise keep us at the cutting edge of formulation science and analytical method development. This expertise enables us to support a wide range of modalities.
Talk to Our Experts or Request a Quote
Our expert team is ready to answer your questions and guide you to the services best suited to your program’s modality, stage and challenge. If your needs are well-defined, we’ll begin the quotation process.
Peptide FAQs
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Peptides are short chains of amino acids, usually comprising fewer than 50 amino acids with a molecular weight of up to 6 kDa. They are an important class of therapeutic compounds used to treat a variety of diseases, including cancer, diabetes, viral infections, and chronic pain. Peptides have strong potency, high selectivity and generally low toxicity, making them valuable tools for current and future therapies.
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Coriolis uses its extensive experience to create stable and robust peptide formulations. We offer a range of stability testing and phase-appropriate analytical methods tailored to peptide characterization, optimizing buffer conditions, counterions and stabilizing excipients.
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Coriolis combines knowledge, expertise and state-of-the-art analytics to design fit-for-purpose study plans. We address issues like solubility, impact of counterions and formulation at high peptide concentrations to minimize gelation, fibrillation and chemical degradation.