Paving the way to a successful AAV product

Paving the way to a successful AAV product

Navigating manufacturing and analytical challenges

Adeno-associated viruses (AAVs) are versatile vectors serving as the leading platform in gene therapy.

In this webinar, Prof. Dr. Susumu Uchiyama will provide an overview of today’s state-of-the art analytical methods for AAV characterization and address key parameters to monitor during process development in AAV manufacturing. Prof. Uchiyama will discuss the rationale behind selecting individual methods for each quality attribute explaining how these analytical approaches contribute to the optimization of the manufacturing process and the assurance of product quality.

Subsequently, Dr. Melanie Schwerdtfeger will present case studies highlighting the measurement of AAV infectivity and the full-to-empty capsid ratio by orthogonal methods such as analytical ultracentrifugation and mass photometry as part of drug product development.

LEARNING OBJECTIVES

• Which analytical methods are appropriate for characterization of AAVs during manufacturing and drug product development?
• Which quality attributes should be monitored during AAV manufacturing to achieve high quality products?
• How can we measure infectivity of AAVs independent of the encoded therapeutic protein?

SPEAKER

Look forward to interesting presentations and a concluding discussion with our speakers Susumu Uchiyama, Professor at Osaka University in Japan and Scientific Advisor at Coriolis Pharma, and Melanie Schwerdtfeger, Scientist at Coriolis Pharma.