Nanoparticulate Delivery Systems
Coriolis Pharma is your expert partner for developing robust and phase-appropriate formulations for nanoparticulate delivery systems. Our specialists perform comprehensive stability, forced degradation studies and cutting-edge particle analysis techniques, offering reliable analytical data essential for the development of a wide range of drug delivery technologies.
We have experience with numerous nanoparticulate drug delivery systems, including exomes, liposomes, polymeric nanoparticles, lipid nanoparticles, lipoplexes and dendrimers.
Nanoparticulate Delivery System Development Services
Coriolis Pharma’s deep expertise in nanoparticulate drug delivery technology and experience with a variety of nanoparticle delivery systems equip us to support the entire product lifecycle.
Specialized Nanoparticulate Delivery System Services and Capabilities
Coriolis offers science-driven solutions and considers the specific challenges of developing a nanoparticulate drug delivery system. Our expert scientists develop a dedicated study design tailored to the needs of your drug delivery system, product type and development phase.
Analytical Development for API Recovery Assessment
Characterizing the API for drug delivery technology requires separating it from the system. Our experts create protocols to recover mRNA from lipid nanoparticles (LNPs), for example, allowing separate analysis of the delivery system and payload. We also develop analytical methods using various techniques to assess the integrity and stability of the API post-recovery.
Characterizing Particle Size Distributions
Characterizing nanometer-sized particles is challenging but crucial for assessing a drug delivery technology’s stability and integrity. Coriolis excels in particle analysis, using advanced and emerging techniques to comprehensively characterize difficult samples. Our scientists continually adopt new technologies and approaches to provide the best analytical solutions for your needs.
Nanoparticulate Delivery System Resources
Publications
February 25, 2019
Publications
September 12, 2018
Comprehensive Biotherapeutic Expertise
Our deep-rooted academic background, drug development and commercialization expertise keep us at the cutting edge of formulation science and analytical method development. This expertise enables us to support a wide range of modalities.
Nanoparticulate Delivery System FAQs
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Drug delivery systems enable a therapeutic molecule to reach its intended target within the body and release its payload in a controlled manner. They enhance the efficacy and safety of treatments, especially when the molecule cannot reach the target by itself, is prone to degradation, has potential off-target toxicity or requires controlled release.
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Nanoparticulate delivery systems improve drug delivery by enhancing the drug’s stability and bioavailability, protecting it from degradation, allowing for targeted delivery to specific cells or tissues and enabling controlled release of the therapeutic agent over time.
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Controlled release benefits therapeutic outcomes by maintaining optimal drug levels in the bloodstream for extended periods, reducing dosing frequency, minimizing side effects by avoiding peak concentrations and improving patient compliance and overall treatment efficacy.